This is in line with several studies showing that obesity-related host signaling, including Insulin-like Growth Factor 1 (IGF-1) [132], Epidermal Growth Factor (EGF) [133,134] and IL pathways [135,136], may impact on CEBP-β expression and activity. The gene discussed is CEBPB; the disease is obesity due to melanocortin 4 receptor deficiency.