EPAS1 and neoplasm: Indeed, HIF-2α is frequently overexpressed in human cancers, and its canonical HIF-α–ARNT pathway activation is associated to the up-regulation of numerous cancer-relevant genes including VEGFA, PGK1 (Phosphoglycerate Kinase 1), and LOX (Lysyl Oxidase) for tumor angiogenesis, stemness, glycolysis, and metastasis, respectively [87,88,89,90].