The DIN central hub pool-like kinase 1 (PLK-1) plays key functions in multiple stages of the cell cycle, including the control of the G2/S checkpoint, centrosome maturation, spindle formation, chromosome segregation, DNA replication, cytokinesis, and meiosis [97,98], and its expression has been positively correlated with several cancers, including glioma [99], thyroid carcinoma [100], head and neck squamous cell carcinoma [101], melanoma [102], colorectal cancers [103], esophageal carcinoma [104], ovarian carcinoma [105], prostate cancer [106], and BC [107]. This evidence concerns the gene PLK1 and colorectal cancer.