Genetic factors are also important in the pathogenesis of NAFLD, among which genes responsible for lipid metabolism can be distinguished, for example, PNPLA3 (patatin-like phospholipase domain-containing 3) and its polymorphisms, or TM6SF2 (transmembrane 6 superfamily member 2) [10]. This evidence concerns the gene PNPLA3 and metabolic dysfunction-associated steatotic liver disease.