Fatty tissue is responsible for the secretion of proinflammatory cytokines such as interleukin (IL) 6, IL-8, or tumor necrosis factor alpha (TNF-α), which affect liver condition, exacerbate NAFLD, and promote its progression to non-alcoholic steatohepatitis (NASH). This evidence concerns the gene TNF and metabolic dysfunction-associated steatohepatitis.