In 1935, Stein and Leventhal first described female PCOS [49], characterized by ovulatory dysfunction, hyperandrogenism, and polycystic ovary, accompanied by neuroendocrine features such as increased serum luteinizing hormone (LH) concentrations (Figure 2) [5,50,51,52,53,54]. This evidence concerns the gene PLOD1 and polycystic ovary syndrome.