Based on our previous research on HIF-1alpha signaling during PCOS development and treatment, the present article will systematically elucidate the role and molecular mechanisms of HIF-1alpha signaling during CGA treatment of PCOS from aspects such as ovarian follicle development, steroid hormone synthesis, inflammatory response, oxidative stress, and insulin resistance (Figure 6). This evidence concerns the gene INS and polycystic ovary syndrome.