Given the regulatory effect of CGA as an antioxidant on the HIF-1alpha signaling pathway, this article takes HIF-1alpha as a breakthrough point to systematically elucidate the role and molecular mechanisms of HIF-1alpha signaling during the treatment of PCOS with CGA, including follicular development and ovulation, steroid hormone synthesis, inflammatory response, oxidative stress, and insulin resistance. This evidence concerns the gene INS and polycystic ovary syndrome.