A synergistic induction of apoptosis and an up-regulated expression of growth arrest and DNA-damage-inducible gene 153 (GADD153), death receptor 5 (DR5), and P21 were shown following the treatment of human lung cancer cells (PC-9 cell line) with a combination of EGCG and synthetic retinoid (Am80). The gene discussed is TNFRSF10B; the disease is lung carcinoma.