Alzheimer’s disease (AD) is a progressive neurodegenerative disorder affecting elderly people worldwide and is mainly characterized by two major pathological hallmarks in the AD brain: extracellular plaques, containing various forms of amyloid-β protein (Aβ), and intracellular neurofibrillary tangles (NFTs), composed of hyper-phosphorylated tau protein [1]. The gene discussed is MAPT; the disease is Alzheimer disease.