Interestingly, known TrxR inhibitors, benzo[1,2,4]triazinones 5a, 5b and pleurotin, as well as compounds that correlate very strongly to their anti-cancer activity, benzo[a]carbazole-1,4-dione 14b, kalafungin, and discorhabdin C, gave negative PCCs to NQO1 expression across the NCI-60 panel (PCC = −0.27 to −0.48, Table 1). This evidence concerns the gene NQO1 and cancer.