To explore the anti-hyperuricemia components in sunflower (<i>Helianthus annuus</i> L.)calathide extract (SCE), we identified abietic acid (AA) via liquid chromatography-mass spectrometry and found an excellent inhibitor of xanthine oxidase (IC<sub>50</sub> = 10.60 μM, Ki = 193.65 nM) without cytotoxicity. Here, XDH is linked to hyperuricemia.