Indeed, in previous studies, gallic acid was proven to be effective in reducing the expression of proteins linked to melanogenesis, including microphthalmia-associated transcription factor (MITF) and tyrosinase-related protein-1 (TRP1), and both tyrosinase activity and melanin production in a dose- and time-dependent manner, allowing it to be used as an adjuvant in various therapeutic formulations to reduce skin hyperpigmentation other than being a useful component in skin lightening and whitening products [42]. This evidence concerns the gene TYRP1 and neoplasm.