For example, cepharanthine inhibited the infection of HIV-1 [74,75,76], HCoV-OC43 [77], PRRSV [78], HTLV-1 [79], and the angiogenesis and growth of human oral squamous cell carcinoma OSCC cells [80] by inhibiting the NF-κB signaling pathway; inhibited the proliferation of breast cancer [81] by activation of AMPK signaling pathway; played an inhibitory role in HSV-1 infection [82], ovarian cancer [83] and bone resorption in vivo [39] by inhibiting the PI3K/Akt pathway. This evidence concerns the gene NFKB1 and oral cavity squamous cell carcinoma.