ACHE and early-onset autosomal dominant Alzheimer disease: High activity of such enzymes (e.g., acetylcholinesterase, AChE) is characteristic of pathologies such as Alzheimer’s disease and up to now, the cholinesterase antagonists donepezil, galantamine and rivastigmine are some of the only functional treatments for Alzheimer’s alongside the N-methyl-D-aspartate antagonist with memantine cotreatment.