Thus, the potential beneficial effects of combining G with AIs were investigated in sensitive (MCF7-aro) and resistant (LTEDaro) BC cells.<h4>Methods</h4>The effects on cell proliferation and expression of aromatase, ERα/ERβ, and AR receptors were evaluated.<h4>Results</h4>Unlike the combination of G with Ana or Let, which negatively affects the Ais' therapeutic efficacy, G enhanced the anticancer properties of the steroidal AI Exe, increasing the antiproliferative effect and apoptosis relative to Exe. Here, ESR2 is linked to breast cancer.