Finally, our group treated a zebrafish model for cystinosis (ctns−/−), an autosomal recessive lysosomal storage disorder caused by a defective or absent lysosomal cystine transporter (cystinosin), and resulting in cystine accumulation, with human CTNS mRNA at the one-cell stage and showed restoration of the kidney phenotype (proteinuria and proximal tubular reabsorption) along with reduction of whole body cystine levels [13]. This evidence concerns the gene CTNS and cystinosis.