In further studies we have now completed and are in the process of publishing, we found that fasudil also reduces tau pathology, including a reduction in phospho-T181 tau immunoreactivity, in brains of the TgF344-AD rat (RK, unpublished observation), a model of AD which develops tau pathology without the addition of a tau transgene as is present in the 3xTg-TD mouse, and, importantly, in neurospheroids generated from human iPSC-derived neurons obtained from AD patients (RK, unpublished observation). This evidence concerns the gene MAPT and Alzheimer disease.