A study by Wang et al. demonstrated that PTBP1 binds the 5′ UTR (untranslated region) of the hypoxia inducible factor 1α (HIF-1α) transcript via its RRM1 and RRM3 domains, destabilizing HIF-1α and promoting an invasive phenotype in a non-small cell lung cancer (NSCLC) model [93]. This evidence concerns the gene RRM1 and non-small cell lung carcinoma.