PLOD3 and osteosarcoma: Studies on osteosarcoma cell lines, which produce large amounts of fibrillar collagens, have shown that the simultaneous deletion of GLT25D1 and GLT25D2 results in growth arrest due to a lack of glycosylation, causing some to hypothesize that the Gal-T activity of LH3/PLOD3 might not be as essential as the Glc-T activity [32].