Dumit at al. performed proteomics analysis of dermal fibroblasts from healthy subjects of various ages and from patients with SSc, and they showed a lower proliferation rate of aged and SSc fibroblasts measured by minichromosome maintenance (MCM) complex proteins (MCM6 and 7), deregulated autophagy measured by higher expression of LC3 protein and an increased level of senescence measured by increased β-galactosidase activity, and higher p16 and p21 levels [72]. This evidence concerns the gene MAP1LC3A and systemic sclerosis.