Since proteome analysis was performed on samples derived from patients with IPF and fNSIP and a decreased expression of ANXA5 protein was detected in both groups of patients, autophagosome–late endosome fusion to form amphisomes (convergence of endocytic and autophagy pathways) can be proposed as the role of the ANXA5 protein in the process of autophagy in those disorders (Table 2, Figure 3). Here, ANXA5 is linked to idiopathic interstitial pneumonia.