Among the nine SNPs associated with both UACR-derived variables and kidney damage, five conserved a direction of effect consistent with the one observed in UACR-derived variables, i.e., higher risk of kidney damage with a higher risk of albuminuria or vice versa (MUC1-rs4072037, KIRREL3-rs4935985, CASZ1-rs880315, rs164748 and rs1860229) and four displayed opposite effects (rs159782, COL4A3-rs55703767, rs1077216, and AS3MT-rs3740393). The gene discussed is COL4A3; the disease is Nephropathy.