ALB and chronic kidney disease: Several GWAS have identified SNPs associated with microalbuminuria (mAlb) [25,26,27,28,29,30,31], urine albumin-to-creatinine ratio (UACR) [25,26,27,28,29,32,33] or albumin excretion rate (AER) [32,34] in CKD and/or DKD, with the most consistent findings related to rs1801239, a T/C-missense substitution in the CUBN gene [26,27,35,36,37], encoding the protein cubilin, involved in renal tubular albumin reabsorption [38].