The dupA in the rs57532727 variant in PRNCR1 was associated with ESRD when compared with macroalbuminuria (OR: 1.70; 95%CI: 1.40, 2.04; p = 4.4 × 10−8) in a GWAS meta-analysis including up to 19,406 individuals of European descent with type 1 diabetes [28], consistent with the association with kidney damage in both the overall and the diabetic cohorts in our study (Supplementary Tables S13 and S15). This evidence concerns the gene PRNCR1 and Nephropathy.