GBA1 and lysosomal storage disease: Gaucher disease (GD—OMIM #230800), one of the most prevalent lysosomal storage disorders, is caused by the deficient activity of glucocerebrosidase enzyme (GCase EC 3.2.1.45) due to biallelic pathogenic variants in the gene encoding the acid β-glucocerebrosidase protein, GBA1 (GRCh37/hg19 Chromosome 1: 155,204,239 to 155,214,653).