Chronic stimulation of the immune system is a hallmark of many lysosomal disorders, including GD, and it is characterized by a markedly elevated level of proinflammatory cytokines, such as Interleukin-1β (IL-1β), Tumor Necrosis Factor- α (TNF-α), and/or Interleukin-6 (IL-6), and chemokines [17]. Here, TNF is linked to lysosomal storage disease.