In a more compelling case implicating human SLO3 in infertility, a man carrying a missense mutation of the Slo3 gene (c.1237A>T: Ile413Phe) exhibited sperm that failed to hyperpolarize, undergo acrosome reaction, and achieve successful fertilization in in vitro fertilization (IVF) procedures [97]. This evidence concerns the gene KCNU1 and Infertility.