PDCD1 and peeling skin syndrome: In cancer patients treated with monoclonal antibodies against CTLA-4, or PD-1, inflammatory diseases including colitis, pneumonitis, arthritis, inflammatory myopathy, vasculitis, nephritis and sialadenitis, resembling pSS, occurred at a frequency of approximately 60% [150,151,152,153]; xerostomia and dry eye due to excretory dysfunction was observed in 5% of patients treated with ICIs [154].