Although most of the genes are indeed downregulated in HNSCC cells expressing miR-30a-3p or miR-30e-3p, as confirmed by RT-qPCR, some of them are overexpressed in either cell lines or in response to either miRNA (such as GADD45, ACVR1, LTBP2, BNC1, SPTBN1, and DPYSL3 in SCC9, Figure 3b). This evidence concerns the gene LTBP2 and head and neck squamous cell carcinoma.