LMNA and familial dilated cardiomyopathy: To this end, we generated Lmnaflox/floxSM22αCre mice to evaluate the effects of combined Lmna deficiency in VSMCs, cardiomyocytes, and cardiac fibroblasts, a situation that occurs in LMNA-DCM patients and provides a more translational model of the potential cross-talk between these cell types.