Recent studies in Pdfra-Cre:Lmnaf/f mice with lamin A/C absence in ~80% of cardiac fibroblasts and ~25% of cardiomyocytes partially recapitulated the LMNA-DCM phenotype, with a median lifespan of ~43 days [24]. The gene discussed is LMNA; the disease is familial dilated cardiomyopathy.