MYH6 and familial dilated cardiomyopathy: Consistent with previous studies in Myh6-Cre:Lmnaf/f mice with lamin A/C deficiency exclusively in cardiomyocytes [22,23], Lmnaflox/floxSM22αCre mice recapitulated the main hallmarks of human LMNA-DCM, including cardiac fibrosis, ventricular systolic dysfunction, ECG alterations, and premature death.