BRAF and familial hypercholesterolemia: In summary, our findings support the suggestion that LDLR plays an important role in the RAS/RAF/MAPK (MEK)/ERK signaling cascade in TC and suggest a synergy between LDL-mediated receptor uptake and BRAF V600E in TC, which could lead to a worse prognosis in the clinical setting of hypercholesterolemia (Figure 8).