In the striatum of SLE mice, there was a significant upregulation of tPA mRNA expression in both age groups (**** p ≤ 0.0001 vs. WTs; Figure 3A), whereas the expression levels of ICAM-1 and VCAM-1 were only increased in older NZBWF1 mice (ICAM-1: **** p ≤ 0.0001 vs. 7 mo WTs; VCAM-1: *** p ≤ 0.001 vs. 7 mo WTs; Figure 3C,D). Here, PLAT is linked to systemic lupus erythematosus.