In the present study, we interrogated two CNS regions that are vulnerable to the effects of NPSLE—the hippocampus and striatum [1,2]—where we investigated the expression of endothelial markers (namely, tPA, uPA, ICAM-1, VCAM-1, BDNF, eNOS and KLF4) and the VIP/PACAP neuropeptide system in a spontaneous animal model of SLE. Here, VCAM1 is linked to systemic lupus erythematosus.