To expand these findings, Wheeler et al. found that the astrocytes of EAE-induced mice and MS patients had a reduced nuclear factor erythroid 2-related factor 2 (NRF2) expression and a higher MAFG transcription factor level, which promoted DNA methylation and inflammation in the CNS and limited anti-inflammatory activity [117]. The gene discussed is NFE2L2; the disease is myeloid sarcoma.