The interaction of VECs with melanoma-derived ECM was shown to induce the activation of the αvβ3/VEGFR-2 signaling pathway, thereby promoting angiogenesis, and the inhibition of integrin αvβ3 binding to the corresponding ligands effectively represses the activation of the FAK-Src complex and VEGFR-2 [11]. Here, KDR is linked to melanoma.