The interaction of vascular endothelial cells with the melanoma-derived extracellular matrix (ECM) induces activation of the αVβ3/VEGFR-2 signaling pathway, thus promoting angiogenesis; additionally, the inhibition of integrin αVβ3 binding to the corresponding ligand effectively suppresses activation of the FAK-Src complex and VEGFR-2 [11]. Here, KDR is linked to melanoma.