These studies suggest further involvement of fetuin-A in the initiation of AV calcification, hence raising the concept that fetuin-A, as an inhibitor of calcification, may prevent valvular calcifications when the calcium phosphate is disrupted, suggesting its correlation to calcium tissue deposition [101], and its levels, is also associated with inflammation and other comorbidities such as chronic kidney disease and diabetes [102]. The gene discussed is AHSG; the disease is calcification.