In the context of aortic calcification, evidence that connects aortic stenosis and Ca2+ dysregulation goes back to a genome-wide association study [123], where calcified valves reveal the upregulation of mRNA levels of RUNX2 concomitant with an increased calcium voltage-gated channel subunit alpha 1 C (CACNA1C) gene [123], which encodes the CaV1.2 L-type voltage-gated Ca2+ channel. Here, CACNA1C is linked to calcification.