IL1RL2 and Alzheimer disease: We also examined IL-36α, IL-36γ, and IL-36R expression in epidermal keratinocytes of AD by immunohistochemistry and found that IL-36α and IL-36γ expression in epidermal keratinocytes, especially in nucleus, was higher in AD skin (Supplementary Figure S1A–D), consistent with previous studies [19,20,21].