Since the neutralization of CD8-positive cytotoxic T-cells is PD-L1 dependent, our data indicate that irrespective of PD-L1 positivity of tumor cells, the PD-L1 positive CAFs can play a critical role in bringing out an additional load of PD-L1 for an effective engagement of PD-1 within a tumor mass. This evidence concerns the gene CD8A and neoplasm.