To understand the tumor–stroma-immune crosstalk, we studied the compartmental pattern of PD-L1, PD-L2, and PD-1 expression in endometrial cancer tissues from over 116 consenting patients with grades 1, 2, and 3 diseases vis-à-vis PD-L1 expression in their matched cultured CAFs. Here, CD274 is linked to endometrial cancer.