In order to test the dominance of one protein over another or their differential distribution in different regions of the tumor and tumor-adjacent normal tissue, we compared the IHC expressions of PD-L1, PD-L2, and PD-1 in (1) epithelium vs. SME, (2) tumor vs. TME, (3) epithelium vs. tumor, and (4) TME vs. SME in tumor and tumor-adjacent normal tissues from 26 patients with EC (Table 1). This evidence concerns the gene PDCD1 and neoplasm.