In this study, we investigated whether the pre-treatment with the natural antioxidant resveratrol, in combination with systemic hyperthermia and cisplatin, can enhance the effect of cisplatin on tumour cells through the modulation of HDAC activity and the HSP70 and HSP90 levels and consequently contribute to direct toxicity on tumour cells, the inhibition of angiogenesis and tumour growth, and ultimately increase the lifespan of mice. Here, HDAC9 is linked to neoplasm.