A synergism between the resveratrol, cisplatin, and hyperthermia promotes the death of immunogenic tumour cells through the induction of damage-associated molecular patterns (DAMPs) such as CRT, HSP70, and HMGB1, and via the remodelling of the tumour microenvironment by the increasing maturation of DCs and macrophages. Here, HMGB1 is linked to neoplasm.