Furthermore, we were interested if resveratrol, applied with or without the whole-body hyperthermia treatment, can enhance the effect of cisplatin by modulating HDAC activity and levels of HSP70 and HSP90 and thus contribute to the direct toxicity on tumour cells, the inhibition of angiogenesis and tumour growth, and consequently the increased lifespan of mice. The gene discussed is HDAC9; the disease is neoplasm.