It is known that chemotherapeutic “drugs” such as cisplatin, doxorubicin, mitomycin C, 5-fluorouracil, and camptothecin, which exert direct cytotoxic effects, also exhibit an indirect cytotoxic activity by “preparing” tumour cells for elimination by immune cells such as NK or cytotoxic T lymphocytes using a Fas or TNF-related apoptosis-inducing ligand (TRAIL)-dependent pathway [34]. The gene discussed is TNFSF10; the disease is neoplasm.