In addition, Zhang et al. [13] showed that pre-treatment with resveratrol reduces the hypoxia-induced expression of HIF-1α and VEGF in human tongue squamous cell carcinoma and hepatoma cells and suggested that HIF-1α/VEGF could be promising drug targets in the development of an effective chemopreventive and anticancer therapy. The gene discussed is VEGFA; the disease is tongue squamous cell carcinoma.