Amato et al. [86] demonstrated that TRPM8 receptors are expressed in the human distal colon under healthy conditions, and that ligand-dependent activation of TRPM8 can reduce spontaneous colonic motility, probably through the opening of large-conductance Ca2+-activated K+ channels, thereby contributing to the onset of pain in IBS patients [34,114]. Here, TRPM8 is linked to irritable bowel syndrome.