In an evaluation study of the expression profile and variants of the genes coding for ion channels in subjects with IBS compared to healthy subjects, the pathophysiological involvement of several genes in the processes related to IBS was highlighted, including Nav1.8, Nav1.1, Nav1.2, Nav1.7, BK, Kir6.1, AQP3, AQP4, AQP7, AQP8, TRPM2, TRPM3, TRPM8, TRPV1, TRPV3, and TRPV4 [30,32]. Here, SCN9A is linked to irritable bowel syndrome.