CLEC7A and infection: Although several in vitro studies demonstrated that blocking Dectin-1 decreased macrophage and dendritic cell cytokine expression after exposure to M. tuberculosis [22,23,24], Dectin-1-deficient mice did not show increased bacterial burden in the lungs following aerosol infection with M. tuberculosis, and there were no observed changes in murine survival, histopathology of lung lesions, or inflammatory responses in M. tuberculosis-infected Dectin-1−/− mice compared to wild-type mice.