In the exosomes derived from AD patients, β-site APP cleaving enzyme 1 (BACE-1), soluble peptide APP beta (sAPPβ), soluble peptide APP alpha (sAPPα), γ-secretase, and Aβ1-42 were found, which closely correlates with the pathogenesis and progression of AD [64]. The gene discussed is BACE1; the disease is Alzheimer disease.