MATR3 and amyotrophic lateral sclerosis: MATR3, which is also bound by the third motif, is a member of a subset of RBPs that have been linked to both sporadic and familial neuromuscular disease as well as to muscular and neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) [28].