Findings using injections of TRH and its analogs are not only in agreement with previous observations showing improvements in neuronal survival in rats with cerebral ischemia [39], but importantly, also show that even delayed treatment of ischemia-injured patients using TRH or its analogs may reduce neuronal loss, thereby increasing their recovery odds and supporting the promising therapeutic role of TRH in the clinical setting. This evidence concerns the gene TRH and ischemia.