TRH and obstructive sleep apnea syndrome: Given the proven efficacy of TRH and its analogs in activating arousal and favoring awakening, as seen in the study of Liu et al. [24], its use will be more advantageous for increasing the respiratory rate in patients with drug-induced breathing depression when it is also important that narcosis be reversed; it will be less advantageous in obstructive sleep apnea, because awakening is an undesirable effect of treating these patients.