In the alveolar rhabdomyosarcoma, H3.3 is overexpressed both in vivo and in cell lines: in this latter system, knockdown of the H3F3A gene reduces the ability of the cell to migrate, suggesting that the H3.3 variant regulates genes involved in motility, like melanoma cell adhesion molecule (MCAM, also known as CD146) [140]. The gene discussed is MCAM; the disease is rhabdomyosarcoma.