HPGD and colorectal carcinoma: In our recent study, we also found that the combination of 15-hydroxyprostaglandin dehydrogenase (HPGD), phosphofurin acidic cluster sorting protein 1 (PACS1), and tyrosyl-DNA phosphodiesterase 2 (TDP2) expression was associated with survival probability (AUC of 0.838) when using whole-transcriptome sequencing, which supports the idea that these genes may be used as potential prognostic biomarkers for CRC [24].