IL1B and B-cell chronic lymphocytic leukemia: Similarly, in the CLL cybrid the ALA (3.2-fold change, p < 0.0001) significantly increased the expression levels of IL1β, whereas the other treatments significantly reduced the levels: amla (0.3-fold change, p < 0.0001), melatonin (0.8-fold change, p < 0.0001), and resveratrol (0.5-fold change, p < 0.0001) (Figure 5).