In the CLL cybrid cells, there were significant increases of TNFα expression levels in response to Ibr + ALA (2.9-fold change, p < 0.0001), Ibr + Amla (2.4-fold change, p < 0.0001), Ibr + Mel (2.8-fold change, p < 0.0001), and resveratrol (two-fold change, p < 0.0001) (Figure 6). Here, TNF is linked to B-cell chronic lymphocytic leukemia.