In contrast, the CLL cybrid showed significantly increased expression levels of IL1β in response to Ibr + Amla (two-fold change, p < 0.0001), Ibr + Mel (3.9-fold change, p < 0.0001), and Ibr + Resv (1.4-fold change, p < 0.0001). The gene discussed is IL1B; the disease is B-cell chronic lymphocytic leukemia.