NOX4 and B-cell chronic lymphocytic leukemia: Interestingly, in the CLL cybrid in response to Ibr + ALA (0.7-fold change, p < 0.0001), Ibr + Amla (0.9-fold change, p < 0.001), Ibr + Mel (0.3-fold change, p < 0.0001), and Ibr + Resv (0.4-fold change, p < 0.0001), there were decreased NOX4 expression levels (Figure 6).