Hence, the administration of KYP-2047, a PREP inhibitor, to A30P transgenic mice decreased the levels of high molecular weight α-syn oligomers, presumably via KYP-2047-induced autophagy [55], although recent data has suggested that KYP-2047 treatment (initiated at the time of symptom onset) may not be protective to nigrostriatal dopaminergic neurons in a transgenic mouse PD model [84]. The gene discussed is PREP; the disease is Parkinson disease.