In response to PAH exposure, a majority of genes (27 out of 32 in PP50, 39 out of 48 in PP100, and 37 out of 57 in PCM) encoding critical enzymes involved in the three pathways were up-regulated; these enzymes included alpha/beta-glucosidase (malZ) and β-fructofuranosidase (INV) (Figure S3). The gene discussed is GAB2; the disease is pulmonary arterial hypertension.