For the cytokines such as IL-1α, IL-1β, IL-6, IL-12p40, MIP-1a, and MCP1, the treatment with nanoparticle F reduced their level compared with the treatment with nanoparticles alone, where a minimal effect from the nanoparticles alone was observed when compared to the untreated 3xTg AD mice (Figure 8B). The gene discussed is CCL2; the disease is Alzheimer disease.