To further examine the effect of the nanoparticles and nanoparticle F in the aging 3xTg AD mice, we plotted individual cytokines data that were previously shown in the literature (as reviewed in [64,65,66] to be related to neuroinflammation and Alzheimer’s disease, including IL-1α, IL-1β, IL-6, TNF-α, IL12-p40, Eotaxin, MIP-1a, and MCP1 (Figure 8B)). The gene discussed is CCL2; the disease is early-onset autosomal dominant Alzheimer disease.