Together, these results suggested that the treatment with nanoparticles alone and nanoparticle F reduced most proinflammatory cytokine expressions in the aging 3xTg AD mice; human Tau and HPTau were previously shown to be highly inflammatory in the brain, and the removal of these aggregated protein species could restore proper brain function by ameliorating neuroinflammation. Here, MAPT is linked to Alzheimer disease.