In the whole acromegaly group, the data reveal that homozygous risk allele carriers (rs1421085 (CC), rs9930506 (GG), rs9939609 (AA)) as well as carriers of only one risk allele, have lower IGF-1 (IGF-1 x ULN) (rs1421085; p = 0.041; rs9930506; p = 0.056; rs9939609; p = 0.029). Here, IGF1 is linked to acromegaly.