The activation of caspases 3/7 following cancer cell treatment was observed not only in BxPC-3 cells treated with MM134, -6, -7, and -9 compounds, but also other derivatives investigated by other authors, confirming the pro-apoptotic potential of the pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine sulfonamides. The gene discussed is CASP3; the disease is cancer.