In our previous study, immunohistochemistry and in situ proximity ligation assay, which detects proximity (<40 nm) between two molecules [13], revealed that β2GPI and HLA-DR had colocalized in endothelial cells of the vessels in the placental decidua obtained from patients with APS with spontaneous miscarriages [11]. This evidence concerns the gene APOH and autoimmune polyendocrinopathy.