Indeed, 71 (91.0%) of 78 anti-β2GPI/HLA-DR antibody-positive women with PRL, 17 (89.5%) of 19 antibody-positive women with FGR, and 22 (91.7%) of 24 antibody-positive women with HDP were not diagnosed with APS. This evidence concerns the gene PRL and autoimmune polyendocrinopathy.