The level of mTOR kinase activity was calculated as pS6rp/elF4E ratio in all tissue samples.GHomas had the highest level of mTOR activity in comparison to NFPA (p = 0.04).The level of mTOR activity did not show any significant correlation with any of the parameters (tumor volume, tumor largest dimension, Knosp’s grading, Ki-67%, and pErk activity).All primary cell culture lines showed mTOR inhibition in response to rapamycin. Here, MKI67 is linked to neoplasm.