CDKN1A and adenoma: Higher levels of miR-16-5p, miR-145-5p, and miR-7g-5p have been found in the plasma of patients with Cushing’s disease (CD) [43] A study comparing patients with invasive and non-invasive PitNET showed that miR-200a expression was increased in invasive samples [44] In profiling CpG island methylation status that included the genes encoding RB1, p14(ARF), p15(INK4b), p16(INK4a), p21(Waf1/Cip1), and p27(Kip1), 88% (30 of 34) of the adenomas displayed methylation of at least one of such cell-cycle regulatory genes [40].