Finally, we showed that the degradation of TG2 is not cell-lineage specific by showing that induced TG2 protein expression can be broken down in myeloid-derived ATRA-differentiated NB4 WT cells in the MCF-7 breast cancer cell line and primary peripheral blood mononuclear cells, thereby sensitising each of these cell types to apoptotic signals (Figure 5A–G). This evidence concerns the gene TGM2 and breast cancer.