GPC-3C densitometry at early (1 week) and late (8 weeks) passages showed higher levels in Cp-Hep and HCC small EVs (Figure 2i,j) We know that GPC-3 is cleaved by Furin-Convertase, and that the domains are still associated by disulfide bindings [32]. The gene discussed is GPC3; the disease is hepatocellular carcinoma.