The effects of bafilomycin A1 on P62 and Lc3B II in the regulation of autophagosome-lysosome fusion and degradation have been widely verified in some studies of melatonin resistance to abdominal aortic aneurysm and quercetin interference with osteosarcoma cells [59,60]. The gene discussed is MAP1LC3B; the disease is abdominal aortic aneurysm.