It should be emphasized that HuHtrA was also found to be induced when BeWo cells were exposed to heat-inactivated C. burnetii and when the cells were incubated with the CoxbHtrA recombinant protein, indicating that infection is not required to activate the expression of HuHtrA but is achieved under bacterial antigen contact or cleavage of E-cad. The gene discussed is CDH1; the disease is infection.