Regarding Tau plasma levels, although the p-Tau181 plasma level (Tau phosphorylated at threonine 181) shows outstanding diagnostic accuracy for differentiating AD dementia from non-AD dementia disorders (AUC = 0.94) [10], it presents a more modest AUC value for pTau181 to separate MCI patients who progressed to AD from those that did not [44]. Here, MAPT is linked to Alzheimer disease.